Status:
RECRUITING
Vigorous- Versus Moderate-intensity Exercise to Reduce Liver Fat in Adults With Obesity and NAFLD
Lead Sponsor:
The University of Hong Kong
Conditions:
Obesity
NAFLD
Eligibility:
All Genders
18-69 years
Phase:
NA
Brief Summary
Non-alcoholic fatty liver disease (NAFLD) arising from obesity has become a global health concern. Although exercise is a cornerstone approach for managing NAFLD, detailed exercise prescription guidel...
Detailed Description
Non-alcoholic fatty liver disease (NAFLD) arising from obesity has become a global health concern. As well as being a risk factor for cardiovascular disease, diabetes, and chronic kidney disease, it h...
Eligibility Criteria
Inclusion
- Cantonese, Mandarin, or English-speaking Chinese,
- aged 18-69,
- centrally obese according to the Asia-specific cut-off (waist circumference 90 cm for males, 80 cm for females) and BMI ≥23 (i.e., overweight as defined by the Hong Kong government),
- with NAFLD (defined as \>5% intrahepatic triglycerides assessed by 1H-MR spectroscopy),
- able to perform the prescribed exercise program. Both men and women will be included to enhance generalizability.
Exclusion
- regular exercise training (\>3 sessions of \>60 min of moderate-intensity exercise training weekly) in the past 6 months,
- medical history of cardiovascular disease, chronic pulmonary or kidney disease, heart failure, cancer, and/or liver disease except NAFLD,
- somatic conditions that limit exercise participation (e.g., limb loss),
- impaired mobility due to chronic disease (e.g., chronic arthritis/osteoarthritis, neurological, musculoskeletal, and autoimmune diseases),
- daily smoking habit,
- excess alcohol consumption (daily ≥20 g of alcohol for men and ≥10 g for women) in the past 1 year,
- consumption of certain drugs (e.g., tamoxifen and estrogen) known to be secondary causes of steatosis,
- surgery and therapy for morbid obesity in the past 6 months and during the study period (e.g., gastric bypass, gastric band, sleeve gastrectomy, gastric reduction duodenal switch, or dietitian-prescribed dietary program).
Key Trial Info
Start Date :
May 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
330 Patients enrolled
Trial Details
Trial ID
NCT06124456
Start Date
May 23 2024
End Date
January 1 2027
Last Update
July 9 2024
Active Locations (1)
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1
LKS Faculty of Medicine
Hong Kong, Hong Kong