Status:
UNKNOWN
Real-time Early Detection of Nephrotoxicity by Urinary Biomarker Analysis With SeroFlow Technology
Lead Sponsor:
National University Hospital, Singapore
Collaborating Sponsors:
Agency for Science, Technology and Research
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The study aims to perform real-time validation of the RenaFAST kit (a point-of-care test kit that quantifies three urinary proteins) in predicting acute kidney injury(AKI) among patients prescribed dr...
Detailed Description
All eligible patients who fulfill the inclusion and exclusion criteria will be approached for consent. The patients with the highest AKI risk (with all 3 urine biomarkers, Clusterin, monocyte chemoatt...
Eligibility Criteria
Inclusion
- Patients who receive a projected ≥7 days of therapy of antimicrobials including aminoglycosides (i.e., gentamicin or amikacin), vancomycin, polymyxin, amphotericin and foscarnet.
- Patients who receive a projected ≥7 days of Calcineurin inhibitors (cyclosporin, tacrolimus)
- Patients who receive a projected ≥7 days of anti-virals (Cidofovir and Ganciclovir)
- Patients who receive Anti-cancer drugs (Chemotherapy such as cisplatin, Ifosfamide, Methotrexate, Pemetrexed) or
- Patients who receive Anti-cancer drugs (Immunotherapy such as immune checkpoint inhibitors as well as types of VGEF inhibitors that are associated with acute kidney injury)
Exclusion
- Patients with AKI prior to therapy initiation.
- Patients with baseline eGFR \< 15 mL/min/1.73m2 (stage 5 chronic kidney disease)
- Patients admitted to intensive care unit at study baseline, as critical illness is a natural confounder to AKI
- Females who are pregnant
- Immediate post-kidney transplant recipients (initial 3 months following transplant).
Key Trial Info
Start Date :
November 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06124885
Start Date
November 1 2023
End Date
December 1 2024
Last Update
November 9 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National University Hospital
Singapore, Singapore