Status:
UNKNOWN
Effect of Vasopressin on Kidney and Cardiac Function in Septic Shock
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Collaborating Sponsors:
FONDECYT de iniciación 11201220
Conditions:
Kidney Injury, Acute
Cardiac Function Failed
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Septic shock is a syndrome characterized by tissue hypoperfusion and hypotension secondary to an uncontrolled infection. It is a frequent cause of admission to the intensive care unit (ICU) and has an...
Detailed Description
A) Theoretical foundations and state of the art A.1 Introduction Septic shock is a syndrome characterized by tissue hypoperfusion and hypotension secondary to an uncontrolled infection. It is a freque...
Eligibility Criteria
Inclusion
- Septic shock diagnosed at ICU admission according to the Sepsis-3
- Mechanical ventilation in place
- Past medical history of chronic hypertension
- Fluid unresponsive status
- Stable norepinephrine dose ≥ 0.1 mcg/kg/min
- Persistent tissular hypoperfusion after initial resuscitation
Exclusion
- Age \< 18 years
- \> 24 h since septic shock diagnosis
- Moderate or severe mitral/aortic disease
- Anticipated surgery during the study period
- Abdominal hypertension grade III
- Pregnancy
- Do-not-resuscitate status
Key Trial Info
Start Date :
November 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06125184
Start Date
November 1 2022
End Date
January 1 2025
Last Update
November 9 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital Clínico Pontificia Universidad Católica de Chile
Santiago, Santiago Metropolitan, Chile, 7561262