Status:
COMPLETED
Beneficial Effects of Probiotics on Improvement of Gut Dysbiosis and Ascending Cholangitis in Patients Received Pancreaticoduodenectomy
Lead Sponsor:
National Cheng-Kung University Hospital
Conditions:
Precancerous Lesions
Eligibility:
All Genders
18-120 years
Phase:
NA
Brief Summary
To determine whether probiotics have beneficial effect on gut dysbiosis and postoperative ascending cholangitis in patients with pancreaticoduodenectomy.
Detailed Description
Gut dysbiosis and postoperative ascending cholangitis (POAC) occurred after pancreaticoduodenectomy (PD). To date, no clinical trial has evaluated the association between gut dysbiosis, POAC and probi...
Eligibility Criteria
Inclusion
- Subjects with peri-ampullary lesions and scheduled to receive pancreaticoduodenectomy (PD) were designed as experimental group; subjects with pancreatic lesions and scheduled to receive distal pancreatectomy (DP) were designed as control group.
- Subjects that already received PD for more than 6 months to join the study and aim to evaluate the effect of probiotics on gut microbiota and postoperative ascending cholangitis (POAC).
- Subjects with the amount of two bottles a day (one provided in the morning and the other in the afternoon) for a duration of 4 weeks.
Exclusion
- Subjects are currently participating in any other clinical trials or studies.
Key Trial Info
Start Date :
March 30 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2019
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06126432
Start Date
March 30 2015
End Date
July 31 2019
Last Update
November 13 2023
Active Locations (1)
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1
National Cheng Kung University Hospital
Tainan, Taiwan, 704