Status:
RECRUITING
Exercise and Emotional Learning in Posttraumatic Stress Disorder
Lead Sponsor:
Christal L Badour
Collaborating Sponsors:
University of Texas at Austin
National Institute of Mental Health (NIMH)
Conditions:
PTSD
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experiment...
Detailed Description
The proposed project would build on our published pilot data and animal models to demonstrate that moderate intensity physical exercise delivered after exposure therapy engages fear circuitry and enha...
Eligibility Criteria
Inclusion
- Adults with PTSD related to interpersonal violence
Exclusion
- Active or recent (within the last 3 months) severe substance use disorder(s)
- Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes
- Significant developmental disabilities
- Current daily benzodiazepine or stimulant use with inability to abstain for study sessions
- Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks)
- Medical condition(s) that prohibit exercise
- History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins
- Magnetic resonance imaging (MRI) contraindication(s)
- Positive pregnancy test
- History of seizure disorder
- Spontaneous seizure(s) within the last 3 months
Key Trial Info
Start Date :
May 13 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06127342
Start Date
May 13 2024
End Date
November 30 2026
Last Update
September 3 2025
Active Locations (2)
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1
University of Kentucky
Lexington, Kentucky, United States, 40506
2
University of Texas
Austin, Texas, United States, 78712