Status:
ACTIVE_NOT_RECRUITING
High Frequency Imaging in Cerebral Amyloid Angiopathy
Lead Sponsor:
Martin Dichgans
Conditions:
Cerebral Amyloid Angiopathy
Eligibility:
All Genders
50+ years
Brief Summary
Cerebral amyloid angiopathy (CAA), caused by amyloid beta depositions in the walls of small cerebral vessels, is remarkably common in the elderly. Its major clinical consequences include intracerebral...
Detailed Description
Cerebral amyloid angiopathy (CAA) is defined as the deposition of β-amyloid in the walls of small cortical cerebral vessels. It is very common in the elderly population with prevalence rates up to 60%...
Eligibility Criteria
Inclusion
- Probable CAA according to the modified Boston criteria with evidence of
- cSS or fSAH
- lobar ICH survivors without cSS or fSAH
- Absence of ICH or microbleed in deep locations (basal ganglia, thalamus, brain stem)
- Absence of infratentorial siderosis or infratentorial SAH
- MR-/CT-/DS-angiography without evidence of cerebral aneurysm, AVM, AV-fistula or other possible etiology for the observed haemorrhagic manifestations
- No history of head trauma resulting in loss of consciousness or radiologically visible traumatic brain injury
- Written informed consent by patient herself/himself prior to study enrolment
Exclusion
- Unwillingness to participate in high-frequency (monthly) follow-up
- Severe medical condition with expected life expectancy \<1 year
- Contraindications for MRI (following local guidelines of the respective study center)
Key Trial Info
Start Date :
March 19 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 31 2026
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT06128824
Start Date
March 19 2019
End Date
May 31 2026
Last Update
September 12 2025
Active Locations (3)
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1
DZNE/Bonn - Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn
Bonn, Germany
2
DZNE/Magdeburg - Universitätsklinikum Magdeburg
Magdeburg, Germany
3
Insitute for Stroke and Dementia Research
Munich, Germany, 81377