Status:
RECRUITING
Is There an Association Between Quadriceps Strength and Different Markers of Fragility in Patients With Cirrhosis?
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Cirrhosis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Physical frailty and malnutrition are important factors in morbidity and mortality in patients with cirrhosis. No study has assessed the validity of Liver Frailty Index (LFI) against reference measure...
Detailed Description
Secondary objective: compare the different strength parameters of patients with cirrhosis (strength endurance, rate of strength development) with healthy subjects.
Eligibility Criteria
Inclusion
- SUBJECT :
- with a diagnosis of liver cirrhosis (regardless of cirrhosis stage and etiology)
- under the care of a physician practising in the University Hospital Estaing in Clermont-Ferrand
- affiliated to the french social security system
Exclusion
- SUBJECT:
- with hepatocellular carcinoma
- with HIV infection
- with hepatic encephalopathy grade ≥ 2
- with cognitive dysfunction
- with contraindication for physical activity
- with knee pain/knee disorders
- pregnant or breastfeeding
- under protective supervision (guardianship, curatorship, protection of the court)
- Inclusion Criteria for healthy volonteers:
- male subjects aged 52 to 62
- female subjects aged 42 to 60
- BMI between 20 and 30 kg/m2
- no musculoskeletal problems limiting physical activity
- level of physical activity \< 3 hours per week
- affiliated to the french social security system
- Exclusion Criteria for healthy volonteers:
- medical or surgical history deemed incompatible with the trial by the investigator
- simultaneous participation in a trial involving a drug or medical device, or period of exclusion from such a trial
- participants protected by law (under guardianship, conservatorship, or protection of the court)
Key Trial Info
Start Date :
November 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06133127
Start Date
November 20 2023
End Date
December 1 2026
Last Update
December 4 2025
Active Locations (1)
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1
CHU clermont-ferrand
Clermont-Ferrand, France