Status:
COMPLETED
Femoral Artery Blood Flow During Rest and One-leg Knee Extensor Exercise in Patients With COPD
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
COPD
Healthy
Eligibility:
All Genders
45-80 years
Phase:
NA
Brief Summary
Doppler ultrasound is generally considered to provide reliable femoral blood flow measurements between rest and exercise, and the blood flow response to exercise is widely believed to be reduced in pa...
Detailed Description
Experimental assessments of changes in skeletal muscle blood flow during exercise in humans are important for elucidating the factors that limit exercise capacity and adaptations, both in healthy huma...
Eligibility Criteria
Inclusion
- Inclusion Criteria for COPD patients:
- Men and women
- 45-80 years
- COPD (GOLD stage I to III)
- Forced expiratory volume in 1 sec (FEV1)/forced vital capacity ratio (FVC) \< 0.8, FEV1 \< 90% of predicted value
- Modified Medical Research Council score (mMRC 0 - 3) Resting arterial oxygenation \> 90%
- Exclusion Criteria for COPD patients:
- Symptoms of ischaemic heart disease
- Known heart failure
- Claudication
- Symptoms of disease within 2 weeks prior to the study
- Participation in pulmonary rehabilitation within 6 months
- Known malignant disease
- Pregnancy
- Unstable cardiac arrhythmic disease
- Renal or liver dysfunction
- Inclusion Criteria for healthy matched controls:
- Men and women
- 45-80 years
- Normal FEV1, FVC, FEV1/FVC, and single-breath diffusion capacity
- Same sex, age (± 3 years) as the COPD patients
- Exclusion Criteria for healthy matched controls:
- Known chronic lung disease
- Known ischaemic heart disease
- Known heart failure
- Symptoms of disease within 2 weeks prior to the study
- Known malignant disease
- Claudication
- Pregnancy
- Unstable cardiac arrhythmic disease
- Renal or liver dysfunction
Exclusion
Key Trial Info
Start Date :
November 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 12 2024
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT06135701
Start Date
November 21 2023
End Date
January 12 2024
Last Update
January 19 2024
Active Locations (1)
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1
Center for Aktiv Sundhed (CFAS), Rigshospitalet, Copenhagen, Denmark.
Copenhagen, København Ø, Denmark, 2100