Status:
RECRUITING
Pharmacoscopy-guided Clinical Standard-of-care in r/r AML
Lead Sponsor:
ETH Zurich
Collaborating Sponsors:
University of Zurich
Insel Gruppe AG, University Hospital Bern
Conditions:
AML, Adult
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
With an overall survival of below 12 months, the outcome of relapsed/refractory AML (RR AML) is poor, making it a critical challenge to identify effective therapies at this stage. The RAPID-01 trial a...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Patient with refractory or relapsed AML according to ELN2022 criteria.
- Age 18-70 years.
- Considered to be eligible for intensive chemotherapy.
- Written informed consent.
- Exclusion criteria
- Acute promyelocytic leukemia (APL) with PML-RARA or one of the other pathognomonic variant fusion genes/chromosome translocations.
- Blast crisis after chronic myeloid leukemia (CML).
- Considered not eligible for intensive chemotherapy.
- Condition of the patient does not allow to wait for PCY results (patient requires immediate treatment).
- PCY not working / patient sample did not pass the QC steps of PCY.
- Any other serious underlying medical, psychiatric, psychological, familial or geographical condition, which in the judgment of the principal investigator may interfere with the project or affect patient compliance.
- Legal incompetence or Subjects lacking capacity to provide informed consent.
- Participation in a clinical trial with an investigational drug within the 30 days preceding and during the present investigation.
Exclusion
Key Trial Info
Start Date :
September 2 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT06138990
Start Date
September 2 2024
End Date
June 30 2026
Last Update
May 16 2025
Active Locations (2)
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1
Inselspital Bern
Bern, Canton of Bern, Switzerland, 3010
2
University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091