Status:
RECRUITING
Clinical Study of Dexmedetomidine Administered Intranasally to Relieve Perioperative Anxiety and Depression in Patients With Colorectal Tumors
Lead Sponsor:
First Affiliated Hospital of Chongqing Medical University
Conditions:
Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Currently, domestic and international research on dexmedetomidine as well as anxiety and depression is more focused on basic research. In terms of clinical research, dexmedetomidine is more often used...
Eligibility Criteria
Inclusion
- Patients with a preoperative diagnosis of colorectal cancer who were to undergo their first oncologic procedure
- Patients who opted for general anesthesia via orotracheal intubation
- Age ≥18 years old
- ASA classification II-III (5) 18.0 \< BMI \< 30.0
- Signed informed consent.
Exclusion
- Diagnosed mental illness or cognitive impairment, or taking antipsychotic, sedative-hypnotic, or anxiolytic-depressant medications
- Serious abnormalities of liver or kidney function.
- Prior alcohol or drug abuse
- Second or third degree atrioventricular block, severe sinus bradycardia (\<50 beats/min), sick sinus node syndrome, congenital heart disease, and other cardiac arrhythmias that severely affect hemodynamic stability
- Grade 3 hypertension
- Any disease of the head, such as cerebral infarcts, epilepsy, head trauma, etc.
- Confirmed diagnosis of non-tumor-induced chronic ( ≥3 months) neuropathic pain
- Inability to understand the meaning of the scale and complete the scoring.
- Women preparing for pregnancy, pregnant women, or breastfeeding
- Patients with myasthenia gravis
- Respiratory function score ≥3
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT06139926
Start Date
December 1 2023
End Date
June 1 2024
Last Update
April 9 2024
Active Locations (1)
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1
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China