Status:
TERMINATED
Two Modes of Mechanical Ventilation for Intensive Care Patients With Low Blood Oxygen Due to Breathing Difficulties
Lead Sponsor:
University Hospital Bispebjerg and Frederiksberg
Conditions:
Hypoxic Respiratory Failure
Ventilators, Mechanical
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The study examines individuals admitted to the intensive care unit due to breathing difficulties resulting in not getting enough oxygen into their bodies. These patient will receive mechanical ventila...
Detailed Description
As hypoxic respiratory failure is an acute condition, this trial will enrol temporarily incompetent patients and obtain consent from the patient's next of kin and an independent medical doctor (trial ...
Eligibility Criteria
Inclusion
- Admitted to the ICU
- Invasive mechanical ventilation with FiO2 ≥ 50% OR PaO2-to-FiO2 ratio \<20 kPa, including PEEP 3 5 cmH20 for at least 6 hours
Exclusion
- Meeting inclusion criteria for more than 24 hours
- Severe bronchospasm, defined as warranting treatment aimed at reversing this i.e. inhalation of anticholinergic or bronchodilator beyond what the patient normally use
- Emphysema where treating physician judges the patient at increased risk for pneumothorax from APRV
- Restrictive lung disease defined as a pre-admission diagnosis of restrictive lung disease
- Undrained pneumothorax
- Hemodynamic instability defined as more than 0.20 microgram/kg/min of norepinephrine or any dose of adrenaline infusion to maintain MAP ≥ 65 mmHg
- Age \< 18 years
- Patients who have received APRV previously during the current ICU admission
- Patients in prone position within the last 24 hours
Key Trial Info
Start Date :
December 8 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 3 2025
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06140056
Start Date
December 8 2023
End Date
September 3 2025
Last Update
September 19 2025
Active Locations (2)
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1
Bispebjerg Hospital
Copenhagen, Denmark, 2400
2
Hvidovre Hospital
Hvidovre, Denmark, 2650