Status:
RECRUITING
Bronchial Epithelium of Children With Post-infectious Bronchiolitis Obliterans
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Bronchiolitis Obliterans
Eligibility:
All Genders
1-6 years
Phase:
NA
Brief Summary
Bronchiolitis obliterans (BO) is an irreversible chronic obstructive pulmonary pathology leading to obstruction and/or obliteration of the small airways. In children, the most common form of BO occurs...
Eligibility Criteria
Inclusion
- Children from 1 month to 6 years hospitalized at the Timone Enfant University Hospital
- Diagnosis of an adenovirus or rhinovirus respiratory infection confirmed on a nasal swab, made upon arrival as part of the child's initial care
- Consent form read, understood, approved and signed by parents before any study procedure
- Affiliation to a social security scheme or beneficiary of such a scheme
- The inclusion criteria for children who were not hospitalized when diagnosed with an adenovirus and rhinovirus respiratory infection at the Timone Enfant University Hospital are:
- Children from 1 month to 6 years old transferred to the Timone Enfant University Hospital
- Show the following signs:
- has. Clinical: clinical signs persist 6 weeks after a viral infection: tachypnea, wheezing and/or persistent hypoxemia b. Scan: mosaic appearance +/- bronchiectasis, atelectasis vs. +/- EFR if performed: obstructive ventilatory disorder not or only slightly reversible after bronchodilators
- Consent form read, understood, approved and signed by parents before any study procedure
- Affiliation to a social security scheme or beneficiary of such a scheme
Exclusion
- Refusal of participation in the study by the family will be a reason for non-inclusion, as well as in the absence of parental authority.
- The existence of an underlying chronic pulmonary pathology (e.g. cystic fibrosis, ciliary dyskinesia).
- A coagulation pathology.
Key Trial Info
Start Date :
December 4 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
450 Patients enrolled
Trial Details
Trial ID
NCT06140901
Start Date
December 4 2023
End Date
November 1 2026
Last Update
April 25 2025
Active Locations (1)
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1
APHM
Marseille, France, 13000