Status:
RECRUITING
PaCIFiC-CUP Classifies Cancer of Unknown Primary
Lead Sponsor:
Sun Yat-sen University
Collaborating Sponsors:
First People's Hospital of Foshan
Third Affiliated Hospital, Sun Yat-Sen University
Conditions:
Unknown Primary Tumors
DNA Methylation
Eligibility:
All Genders
18-80 years
Brief Summary
This study aims to initially utilize machine learning on pan-cancer DNA methylation data from public databases to construct a DNA methylation classification model (PaCIFiC-CUP, pan-cancer integrated f...
Eligibility Criteria
Inclusion
- The patient specimens were obtained from the Sun Yat-sen University Cancer Center and affiliated cooperating centers, with written consent from the patients authorizing the use of the specimens for research purposes.
- Following standard assessments (medical history, physical examination, complete blood count, biochemistry, computed tomography scans of the neck, chest, abdomen, and pelvis, targeted evaluations of all symptomatic areas, pathology, and immunohistochemistry), the diagnosis was determined as a primary site unknown tumor (including adenocarcinoma, squamous cell carcinoma, undifferentiated carcinoma, neuroendocrine carcinoma, sarcoma, etc).
- The diagnosis was confirmed at the participating institution and the patient had received systemic therapy.
- Complete clinical, pathological, and follow-up data for the patients can be obtained.
- ECOG performance status score: 0-2 points.
Exclusion
- Pregnant or lactating female patients.
- Tumor tissue sample size is too small (tumor tissue accounts for \<70% in the biopsy or slice tissue).
- Organ transplant or history of non-autologous (allogeneic) bone marrow or stem cell transplantation.
- History of previous tumors, with the current condition being a recurrent tumor.
- Hematological malignancies (excluding lymphoma).
- Other diseases that may severely impact patient survival, such as severe cardiovascular or cerebrovascular diseases, sepsis, severe trauma or burns, etc.
Key Trial Info
Start Date :
July 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06140992
Start Date
July 1 2023
End Date
December 31 2025
Last Update
June 18 2025
Active Locations (1)
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1
Sun Yat-sen university cancer center
Guangzhou, Guangdong, China, 510060