Status:
NOT_YET_RECRUITING
Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrillation (LYSIS)
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Collaborating Sponsors:
521 Hospital of NORINCO Group
Shaanxi Provincial People's Hospital
Conditions:
Atrial Fibrillation
Intracardiac Thrombus
Eligibility:
All Genders
18-80 years
Brief Summary
This study aims to analyze changes in the immune status, metabolic status, and host microbiome community structure in non-valvular atrial fibrillation patients with intracardiac thrombus. Additionally...
Detailed Description
The researcher-initiated clinical cohort study is a national multicenter, retrospective-prospective study of non-valvular atrial fibrillation patients with intracardiac thrombus, based on molecular bi...
Eligibility Criteria
Inclusion
- Age ≥18 years old, age ≤80 years old
- Patients with atrial fibrillation detected by routine surface 12-lead electrocardiography or Holter
- Transesophageal echocardiography confirmed the presence of cardiac thrombus, and the patient had not received any anticoagulant therapy
Exclusion
- Echocardiography confirmed valvular heart disease
- Contraindications to anticoagulants
- Patients with the previous history of hemorrhagic stroke
- Low platelet count or functional platelet defects
- Congenital or acquired coagulation or bleeding disorders
- Abnormal liver function (liver enzymes \>2 times the upper limit)
- Renal failure (endogenous creatinine clearance \<30ml/min)
- Surgery was planned within the intended study time or had been operated within 30 days before the study
- Other comorbidities that can cause bleeding, such as tumors
- Patients with autoimmune diseases or immunodeficiency, or patients who are currently using immunosuppressants and immunomodulators
- Patients are currently participating in other clinical studies
Key Trial Info
Start Date :
December 31 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06141538
Start Date
December 31 2024
End Date
December 31 2030
Last Update
April 4 2024
Active Locations (1)
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1
First Affiliated Hospital of Xian Jiantong University
Xi'an, Shaanxi, China, 710061