Status:
COMPLETED
Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing
Lead Sponsor:
University Ghent
Collaborating Sponsors:
Fund for Scientific Research, Flanders, Belgium
Conditions:
Low Back Pain
Low Back Pain, Recurrent
Eligibility:
FEMALE
18-45 years
Brief Summary
Although the cause of persistent non-specific low back pain (LBP) remains unknown, structural and functional alterations of the brain, alterations in the lumbar muscles and dysfunction of the central ...
Detailed Description
Introduction: Chronic pain is one of the most disabling symptoms in several medical conditions, including LBP and fibromyalgia. A crucial factor for the persistence of recurrent/chronic pain are alter...
Eligibility Criteria
Inclusion
- Dutch speaking female participants (age between 18 and 45 years).
- Non-specific recurrent LBP patients experiencing a period of remission at the moment of testing. Patients have to meet the criteria for recurrent LBP (in remission) as described by De Vet et al. (2002) and D'Hooge et al. (2013).
- Non-specific recurrent LBP patients experiencing a pain flare at the moment of testing. Patients have to meet the criteria for recurrent LBP (during pain flare) as described by De Vet et al. (2002) and D'Hooge et al. (2013).
- Participants experiencing non-specific chronic LBP (meeting the International Association for the Study of Pain \[IASP\] criteria)
- Participants diagnosed with fibromyalgia according to the American College of Rheumatology (ACR) criteria (2010)
- Healthy volunteers with no history of serious respiratory, orthopedic, neurologic or circulatory conditions. No history of low back pain (i.e. low back pain in this case is defined as a period of symptoms lasting a minimum of 2 consecutive days and for which a paramedic is consulted). Participants with a history of spinal surgery, spinal trauma or spinal deformities are also excluded. Healthy participants will be matched for age and BMI with included participants experiencing chronic/recurrent LBP or fibromyalgia.
Exclusion
- Pregnancy or breastfeeding in the past year
- Contraindications for MRI (e.g. electrical/mechanical implants or electrodes in de body, eye/skin injury by metal fragments in the past, etc)
- BMI lower than 18 or higher than 30
- Participant performed specific trunk muscle training in the past year.
- Participating in sports at a professional level
Key Trial Info
Start Date :
October 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 30 2021
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06143319
Start Date
October 1 2015
End Date
October 30 2021
Last Update
November 22 2023
Active Locations (1)
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1
Ghent University, vakgroep revalidatiewetenschappen
Ghent, Oost-Vlaanderen, Belgium, 9000