Status:
NOT_YET_RECRUITING
HIIT in Isolated IFG: A Proof-of-Concept Study
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Isolated Impaired Fasting Glucose
Eligibility:
All Genders
35-65 years
Phase:
NA
Brief Summary
This pilot randomized controlled trial will involve 34 physically inactive adults aged 35-65 years with overweight or obesity and isolated impaired fasting glucose (i-IFG). The study aims to assess th...
Detailed Description
This 1:1 proof-of-concept randomized controlled trial (RCT) will involve 34 physically inactive adults aged 35-65 years who are overweight or obese and have isolated impaired fasting glycemia (i-IFG)....
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Males and females aged 35-65 years
- Any race or ethnicity
- BMI ≥25 kg/m2 (≥23 kg/m2 if Asian decent)
- Physically inactive (\<150 min of moderate-intensity or \<75 min of vigorous-intensity aerobic physical activity/week)
- Will be residing in the same location until completion of the study
- Isolated impaired fasting glucose on the OGTT: FPG 100-125 mg/dl and 2-hr plasma glucose \<140 mg/dl
- Exclusion criteria:
- History of diabetes
- Regular exercise training in the past 6 months
- Enrolled in weight loss programs in the past 6 months
- Following a specific diet (e.g., ketogenic, Mediterranean)
- Pregnant women
- Breastfeeding
- Smokers
- Taking medications known to affect glucose tolerance (e.g., steroids)
- Taking beta-blockers and calcium channel blockers
- Taking weight loss medications
- Underwent bariatric surgery
- Anemia
- History of chronic illnesses (e.g., stroke)
- Individuals satisfying the eligibility criteria will undergo an OGTT (0, 30, 120 min), and those diagnosed with i-IFG (FPG 100 or 110-125 mg/dl and 2-hr PG \<140 mg/dl) will be recruited to the study.
Exclusion
Key Trial Info
Start Date :
June 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT06143345
Start Date
June 1 2026
End Date
December 30 2026
Last Update
January 9 2026
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