Status:
COMPLETED
Response to Neoadjuvant Chemoimmunotherapy in Resectable Locally Advanced Oral Cancer
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions:
Oral Cancer
Eligibility:
All Genders
Brief Summary
The goal of this observational study is to investigate the effectiveness of neoadjuvant chemoimmunotherapy (NACI) regimens in treating advanced oral squamous cell carcinoma (OSCC) patients. We analyze...
Eligibility Criteria
Inclusion
- Patients with advanced OSCC who received NACI before surgery
- Confirmation of primary OSCC by two experienced pathologists;
- Clinical stage III/ IVA (cT1-2/cN1-2/M0 or cT3-4a/cN0-2/M0) according to the 8th Edition of American Joint Committee on Cancer (AJCC) guideline;
- An Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1;
- No prior anti-cancer therapy;
- Locally resectable advanced tumor evaluated by a head and neck surgeon.
- Advanced OSCC patients who only received surgery
- A histopathologic diagnosis of primary OSCC;
- A clinical stage of III/IVA (AJCC, 8th edition);
- An ECOG performance status of 0 to 1.
Exclusion
- Patients with advanced OSCC who received NACI before surgery
- Patients with other pathological types, without NACI or Surgery;
- Incomplete pre-treatment data;
- Lost to follow up were excluded from the study.
- Advanced OSCC patients who only received surgery
- Patients who had received other therapies targeting the head and neck region before the surgery or those with evidence of recurrence or metastasis, as assessed by physical examination reports or imaging studies before surgery
- Lost to follow up.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2022
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT06143761
Start Date
December 1 2020
End Date
June 30 2022
Last Update
November 22 2023
Active Locations (1)
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1
Sun Yat-Sen Memorial Hospital
Guangzhou, Guangdong, China, 510120