Status:
RECRUITING
Metagenomic Next-Generation Sequencing Guides Anti-Infection Strategies
Lead Sponsor:
Guangzhou 8th People's Hospital
Conditions:
AIDS
Pneumonia
Eligibility:
All Genders
18-65 years
Brief Summary
This study aims to observe the effectiveness of clinical application in guiding anti-infection treatments in AIDS patients with severe pneumonia and/or sepsis using Metagenomic Next-Generation Sequenc...
Detailed Description
The study focuses on AIDS patients with severe pneumonia and/or sepsis, divided into groups based on whether metagenomic next-generation sequencing technology is used in the real world or not. The gro...
Eligibility Criteria
Inclusion
- Confirmed HIV infection;
- Progression to AIDS stage: CD4+ count \<200 cells/ul and/or occurrence of AIDS opportunistic infections;
- Age between 18 and 65 years;
- Meeting the diagnosis of severe pneumonia or septic shock:
- The criteria for severe pneumonia diagnosis refer to the 2021 ATS (American Thoracic Society) and IDSA (Infectious Diseases Society of America) guidelines for the treatment of community-acquired pneumonia;
- The criteria for septic shock refer to the Chinese Society of Critical Care Medicine's "Chinese Guidelines for the Emergency Treatment of Sepsis/Septic Shock (2018).
Exclusion
- Coexisting central nervous system lesions, severe liver disease, or cirrhosis;
- Concurrent AIDS-related or unrelated tumors;
- Women who are pregnant or breastfeeding;
- Severe underlying diseases of the heart, lungs, liver, kidneys, etc.;
- Alcohol abuse or drug use;
- The researcher believes that the overall condition of the subject affects the evaluation and completion of the trial.
Key Trial Info
Start Date :
October 23 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 23 2027
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT06145841
Start Date
October 23 2023
End Date
October 23 2027
Last Update
November 24 2023
Active Locations (1)
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1
Linghua Li
Guangzhou, Guangdong, China, 510060