Status:
RECRUITING
Prophylactic Tributyrin Supplementation in Acute Pancreatitis
Lead Sponsor:
St. Antonius Hospital
Conditions:
Acute Pancreatitis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The goal of this clinical trial is to investigate the possible effects of tributyrin supplementation in patients with a first episode of acute pancreatitis. The main question it aims to answer is: • ...
Detailed Description
Rationale: Acute pancreatitis (AP) is a common gastrointestinal disorder requiring acute hospitalization. Around 20% of patients that present with acute pancreatitis eventually develop severe complica...
Eligibility Criteria
Inclusion
- First episode of acute pancreatitis (AP)
- Able to read and/or understand the study procedures
- Able to give informed consent (or their legal representatives)
- \<24 hours after diagnosis of AP
- \<72 hours after onset of symptoms of AP
Exclusion
- Pancreatitis due to endoscopic retrograde cholangiopancreatography (ERCP), malignancy or trauma
- Post-operative pancreatitis
- Intra-operative diagnosis
- Immunocompromised patients (history or current immunosuppressive treatment such as chemotherapy, radiotherapy, longer use of immunosuppressive medication or recent high doses, immunocompromised illness' such as AIDS, leukemia, lymphoma)
- Pregnancy and/or lactation
- Age \<18 years old
- History of recurrent or chronic (MANNHEIM criteria25) pancreatitis (see Appendix 15.1 for definition)
Key Trial Info
Start Date :
February 12 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT06147635
Start Date
February 12 2024
End Date
January 1 2027
Last Update
June 20 2024
Active Locations (2)
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1
Reinier de Graaf Gasthuis
Delft, South Holland, Netherlands, 2625AD
2
St. Antonius Hospital
Nieuwegein, Utrecht, Netherlands, 3435CM