Status:
UNKNOWN
Treatment of Oral Chronic Graft-versus-host Disease With Human Umbilical Cord Mesenchymal Stem Cell Dressing
Lead Sponsor:
Southwest Hospital, China
Collaborating Sponsors:
Xinqiao Hospital of Chongqing
Conditions:
Mesenchymal Stem Cells
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
Chronic graft-versus-host disease (cGVHD) is a clinicopathological syndrome caused by donor lymphocytes attacking the recipient's organs during the process of reestablishing donor immunity after allog...
Eligibility Criteria
Inclusion
- No gender limitation, age \<65 years old; KPS score \>60, estimated survival \>3 months.
- No serious damage to the function of major organs of the whole body.
- Donor hematopoietic reconstruction was stable (neutrophils \>0.5×10\^9/L, platelets \>20×10\^9/L).
- Stable control of primary blood diseases.
- Voluntary examination, informed consent.
Exclusion
- Have severe heart, kidney or liver dysfunction.
- Those combined with other malignant tumors need treatment.
- There are clinical symptoms of brain dysfunction or severe mental illness and the inability to understand or follow the research protocot4. Patients who cannot be guaranteed to complete the necessary treatment plan and follow-up observation.
- 5\. Patients with severe acute allergic reactions. 6. Clinically uncontrolled active infection. 7. Patients who are participating in other clinical trials. 8. Researchers believe that the subject is not suitable for clinical trials for other reasons.
Key Trial Info
Start Date :
November 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2023
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT06149832
Start Date
November 30 2023
End Date
November 30 2023
Last Update
November 29 2023
Active Locations (1)
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1
Xinqiao Hospital
Shapingba, Chongqing Municipality, China