Status:
COMPLETED
Value of an Intrathecal Synthesis Index of Specific Antitreponema IgG for Neurosyphilis Diagnosis
Lead Sponsor:
University Hospital, Geneva
Collaborating Sponsors:
Swiss HIV Cohort Study
Swiss National Science Foundation
Conditions:
Neurosyphilis
Eligibility:
All Genders
18+ years
Brief Summary
A retro-prospective case-control Swiss study was conducted to evaluate the diagnostic performance of measuring an antibody index (AI) for intrathecal synthesis of specific anti-Treponema pallidum (T. ...
Detailed Description
The diagnosis of neurosyphilis (NS) lacks a true "gold standard" which makes the diagnosis challenging while consequences of a misdiagnosis are potentially severe. The aim of this study was to evaluat...
Eligibility Criteria
Inclusion
- All patients who have serum / CSF sample pairs collected concomitantly (3 days maximum interval between blood test and lumbar puncture).
- Age \> or = 18 years old.
Exclusion
- All patients for whom the stored samples do not meet the needs of the diagnostic study, or whose serum and CSF collection date is more than 3 consecutive days.
- Age \< 18 years old.
- No written consent form for the prospective part.
Key Trial Info
Start Date :
March 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
181 Patients enrolled
Trial Details
Trial ID
NCT06152393
Start Date
March 1 2019
End Date
December 31 2022
Last Update
November 30 2023
Active Locations (1)
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1
Laurence Toutous Trellu
Geneva, Switzerland, 1204