Status:
COMPLETED
Switch From Etravirine to Doravirine as a Part of Antiretroviral Combination
Lead Sponsor:
Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
Conditions:
HIV Infections
Eligibility:
All Genders
18+ years
Brief Summary
The main objective of the SWEED study is to determine whether doravirine containing ART is able to maintain viral suppression at W48 in HIV-1 infected people living with HIV (PLWH) receiving etravirin...
Detailed Description
The evolution of HIV infection from fatal to chronic has been enabled by advances in development and access of antiretroviral treatment (ART), which has also resulted in life expectancy of PLWH approa...
Eligibility Criteria
Inclusion
- Patients over 18 years
- With HIV-1 infection
- On a regimen containing etravirine QD or BID combined with at least one other antiretroviral from any class except NNRTI
- Who had switched for a regimen containing doravirine combined with the same number of other antiretrovirals
- With plasma HIV-RNA \<50 copies/mL for at least 12 months (one blip \<200 copies/mL permitted) at time of switch to doravirine
- With at least 2 available pVL after the switch, and at least 48 weeks between the switch and the last available pVL\*
- Who gave their non-opposition for the study
- For patients who stopped doravirine-based treatment or were lost to follow-up before 48 weeks, only the theoretical duration of follow-up will be taken into account (time between the switch and the date of analysis)
Exclusion
- \- Subject under " sauvegarde de justice " (judicial protection due to temporarily and slightly diminished mental or physical faculties), or under legal guardianship
Key Trial Info
Start Date :
December 8 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 15 2024
Estimated Enrollment :
109 Patients enrolled
Trial Details
Trial ID
NCT06155019
Start Date
December 8 2023
End Date
September 15 2024
Last Update
January 10 2025
Active Locations (1)
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1
Pitié-Sapêtrière Hospital
Paris, France, 75013