Status:
RECRUITING
HD-EEG Connectivity Changes in Migraine Patients Undergoing Treatment With Anti-CGRP mAbs
Lead Sponsor:
IRCCS National Neurological Institute "C. Mondino" Foundation
Conditions:
Migraine Disorders
Chronic Migraine
Eligibility:
All Genders
18-65 years
Brief Summary
Migraine is a leading cause of disability with an estimated prevalence of 12% in Europe. The headache field witnessed a breakthrough since the introduction of specific preventive therapies which prove...
Detailed Description
Electroencephalogram (EEG) is widely available as a powerful mean to non-invasively study brain connectivity features in migraine patients. High density EEG, by means of a minimum of 64 up to 256 elec...
Eligibility Criteria
Inclusion
- Episodic or chronic migraine diagnosis according to ICHD-3 criteria
- Indication to BoNT-A or mAbs treatment according to AIFA criteria
- Brain MRI performed within 24 months from enrolment
Exclusion
- Previous or actual history of epilepsy
- Diagnosis of dementia o mental retardation
- Diagnosis of psychiatric illness according to Diagnostic and Statistical Manual of Mental Disorders V
- Other concomitant type of headache (except for sporadic tension type headache)
- Chronic pain conditions
- Pregnancy or breastfeeding
- Concomitant use of electrical stimulators, pace-makers, metallic clips or other metallic foreign bodies
- Previous head surgery
- Ongoing neuroactive prevention therapies or other drugs, or psicoactive substances possibly interfering with EEG recording (eg benzodiazepines)
- Other conditions possibly influencing EEG recording
- Brain anomalies detected on MRI
Key Trial Info
Start Date :
January 14 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06155123
Start Date
January 14 2020
End Date
June 1 2024
Last Update
January 16 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Headache Science & Neurorehabilitation Center
Pavia, Italy, 27100