Status:
RECRUITING
Tolerance in Beekeepers
Lead Sponsor:
University Hospital Plymouth NHS Trust
Collaborating Sponsors:
University of Plymouth
Conditions:
Bee Sting
Eligibility:
All Genders
18+ years
Brief Summary
Beekeepers experience multiple bee stings each year. Many of these beekeepers (25-60%) become sensitized to bee venom through the production of specific antibodies that target the bee venom. Although ...
Detailed Description
Beekeepers experience multiple stings each year many of whom (25-60%) become sensitised to bee (apis mellifera) venom through the production of IgE antibodies. However only a small proportion of the s...
Eligibility Criteria
Inclusion
- \- Group 1 inclusion criteria.
- Individuals naive to beekeeping (\<2 previous bee stings, none in the last 24 months)
- no history of anaphylaxis to stings. Group 2 inclusion criteria.
- Beekeepers with \> approximately 10 stings/year who have been beekeeping for \>3 years.
- No history of anaphylaxis to bee venom. Group 3 inclusion criteria
- Beekeepers with diagnosis of anaphylaxis to bee venom in the last 12 months who are sensitised to bee venom (as evidenced by positive specific IgE and positive skin test to bee venom)
Exclusion
- Unable to understand protocol/consent.
- Unable to commit to follow up visits.
- Participants with a known history of mastocytosis or under investigation for suspected mastocytosis.
- Participants undergoing desensitisation treatment to bee venom before the first visit.
- Participants being treatment with immunosuppressive medications. being treatment with immunosuppressive medications.
Key Trial Info
Start Date :
January 22 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06156046
Start Date
January 22 2024
End Date
October 1 2027
Last Update
April 30 2025
Active Locations (1)
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1
Derriford Hospital - University Hospitals Plymouth
Plymouth, Devon, United Kingdom, PL65FP