Status:
COMPLETED
Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal Disease
Lead Sponsor:
University Hospital Freiburg
Collaborating Sponsors:
Jena University Hospital
Johannes Gutenberg University Mainz
Conditions:
Liver Cirrhosis
Hepato-Renal Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this retrospective study is to evaluate the treatment response to terlipressin and albumin in patients with suspicion of HRS-AKI and signs of chronic parenchymal kidney disease (HRS-AKI-lik...
Detailed Description
Liver cirrhosis is a major cause of global health burden, accounting for 31 million disability adjusted life years and 1 million deaths worldwide in 2010. In the natural history of liver disease, ther...
Eligibility Criteria
Inclusion
- Patients with cirrhosis confirmed by histology or liver stiffness or with unequivocal signs in ultrasound, endoscopy and/or blood tests hospitalized between 1st of January 2018 and 31st of December 2022.
- Evidence of ascites due to portal hypertension
- Clinical suspicion of HRS-AKI or HRS-AKI-like syndrome (in case of previously diagnosed CKD)
- Pre-existing data on kidney function (SCr and eGFR) minimum 3 months prior to admission in a stable situation
- Dip stick urine test results (screening for proteinuria and hematuria) before initiation of AKI-treatment
- Vasoactive treatment for the management of HRS-AKI, as defined by the administration of terlipressin or noradrenalin plus albumin
- Age ≥ 18 years old
Exclusion
- Uncontrolled shock
- Patients with cardiac cirrhosis as defined by the development of cirrhosis in a patient with chronic heart failure due to a primary cardiac disease (ischemic cardiomyopathy, hypertensive cardiomyopathy, etc.)
- Patients with hepatocellular carcinoma BCLC C or D
- Patients receiving renal replacement therapy at baseline
Key Trial Info
Start Date :
March 3 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
490 Patients enrolled
Trial Details
Trial ID
NCT06161766
Start Date
March 3 2024
End Date
December 31 2024
Last Update
December 5 2025
Active Locations (4)
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1
University Medical Center Freiburg
Freiburg im Breisgau, Germany
2
University Medical center Jena
Jena, Germany
3
University Medical Center Mainz
Mainz, Germany
4
University Hospital Münster
Münster, Germany