Status:
ENROLLING_BY_INVITATION
Potential Biomarkers and Pathogenic Mechanism for Reflux Aspiration-induced Lung Injury.
Lead Sponsor:
Shanghai Zhongshan Hospital
Conditions:
ARDS, Human
Aspiration Pneumonia
Eligibility:
All Genders
18-99 years
Brief Summary
There is limited research on aspiration pneumonia-induced ARDS (Acute Respiratory Distress Syndrome), and currently there is a lack of studies on corresponding biomarkers and pathogenic mechanisms. We...
Detailed Description
Aspiration pneumonia leading to acute respiratory distress syndrome (ARDS) is not uncommon in clinical practice, but sometimes it occurs covertly and is not easily detected by doctors or family member...
Eligibility Criteria
Inclusion
- The patient is between 18-99 years old. The patient meets the diagnostic criteria for ARDS upon admission to the ICU or during hospitalization, and requires mechanical ventilation with endotracheal intubation.
- Within 24 hours of endotracheal intubation, bronchoscopy is performed for diagnostic or therapeutic purposes, and BALF is collected.
- PH, amylase, and cytokines are tested within 24 hours. The patient, legal guardian, or authorized patient representative must voluntarily sign an informed consent form approved by the corresponding institutional review board. If the patient signs the consent form, the person obtaining consent must ensure that the patient is in a sufficient condition to provide informed consent.
Exclusion
- Clinical diagnosis of left ventricular failure Lung cancer-primary or metastatic Hematologic malignancy Acute gastrointestinal bleeding precluding enteral feeding Severe immunosuppression, defined as cytotoxic therapy within 15 days or White blood cell count of 5000 7) Use of steroids: 0.25 mg/kg/day of prednisone (or an equivalent dose of corticosteroids) Use of nonsteroidal anti-inflammatory (including aspirin) drugs within the last 24 hrs Known to be HIV positive Moribond at entry Pregnancy or positive pregnancy test
Key Trial Info
Start Date :
November 28 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 28 2026
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT06164639
Start Date
November 28 2023
End Date
November 28 2026
Last Update
July 30 2025
Active Locations (1)
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1
Zhongshan Hospital Fudan University
Shanghai, China