Status:
COMPLETED
Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment
Lead Sponsor:
Alexandria University
Conditions:
Retinal Detachment
Proliferative Vitreoretinopathy
Eligibility:
All Genders
Up to 14 years
Phase:
NA
Brief Summary
EVALUATION OF 5-FLOUROURACIL AND LOW MOLECULAR WEIGHT HEPARIN INTRAOPERATIVE INFUSION IN PREVENTING PROLIFERATIVE VITREORETINOPATHY IN HIGH RISK PEDIATRIC RHEGMATOGENOUS RETINAL DETACHMENT
Detailed Description
After informed consent, children under 14 years of age with high-risk PRRD underwent pars plana vitrectomy and silicone oil injection with scleral buckle divided into 2 groups in prospective randomize...
Eligibility Criteria
Inclusion
- Children under 14 years of age with RRD undergoing primary repair Preoperative PVR grade B or higher High risk RRD: uveitis; large, giant, or multiple tears; vitreous hemorrhage; preoperative choroidal detachments; aphakia; and large detachments involving greater than two quadrants of the eye
Exclusion
- Children with RRD related to penetrating ocular trauma involving the posterior segment Previous RD repair surgery Uncontrolled glaucoma or other concomitant ocular morbidities Patients with bleeding diathesis, hepatic and renal failure Corneal opacity sufficient to impair surgical view No light perception vision Inability to complete follow-up
Key Trial Info
Start Date :
October 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 21 2023
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT06166914
Start Date
October 21 2021
End Date
May 21 2023
Last Update
December 19 2023
Active Locations (1)
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1
Faculty of Medicine, Alexandria University
Alexandria, Egypt