Status:
RECRUITING
Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases
Lead Sponsor:
Cairo University
Conditions:
Guillain-Barre Syndrome
Eligibility:
All Genders
20-55 years
Phase:
NA
Brief Summary
The aim of the current study is to compare the effect of ventilator trigger sensitivity adjustment versus threshold inspiratory muscle training on arterial blood gases in mechanically ventilated patie...
Detailed Description
Failed extubations are not uncommon in most ICUs, the failure rate ranging from 2 to 20%. Since failed extubation is associated with greater hospital morbidity and mortality and longer length of stay,...
Eligibility Criteria
Inclusion
- Difficult to wean Guillain barre patients who have been on MV for at least 48 hours. Difficult to wean subjects have been defined as those who fail the first spontaneous breathing trial (SBT)and may require up to 3 SBTs or up to 7 d from the first attempt to achieve successful weaning (B´eduneau G. et al.,2017) and (Annia F. et al.,2019).
- Age: \>18 years.
- Both sexes will be included.
- Ventilator mode: Pressure support mode with FiO2≤ 0.5, positive end expiratory pressure (PEEP) will be\<8-10cm/H2Oand respiratory rate \< 25.
- Conscious oriented patient with Glasgow coma score ≥13.
- Alertness will be titrated to a Riker Sedation Agitation Score of 4.
- PH\>7.25, arterial oxygen saturation \>90%.
- Cardiovascular stability.
- Maximal inspiratory pressure from 15 to 30 cm H2O and able to trigger spontaneous breaths on ventilator.
Exclusion
- Persistent hemodynamic instability as life threatening arrhythmias, acute heart failure.
- Severe breathlessness, when spontaneously breathing.
- Any progressive neuromuscular disease that would interfere with responding to inspiratory muscle training (non-stationary course).
- Spinal cord injury.
- Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs.
- Patients on heavy sedation and respiratory muscle paralysis.
- High peak airway pressure (barotraumas).
- BMI ≥ 40.
Key Trial Info
Start Date :
May 2 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06167239
Start Date
May 2 2023
End Date
December 1 2024
Last Update
December 17 2024
Active Locations (1)
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1
Kasr Al Ainy School of Medicine
Cairo, Egypt