Status:
RECRUITING
Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Multi-organ Failure After Severe Trauma
Eligibility:
All Genders
18+ years
Brief Summary
Severe trauma remains the leading cause of death in people under 50, and is associated with high morbidity, including severe disability, with a substantial socio-economic impact. Secondary to trauma, ...
Detailed Description
The investigators plan to include 60 patients over 18 years old with severe trauma, defined with an ISS≥9 and 20 healthy volunteers 18 years old as a reference group. Blood and urine samples will be ...
Eligibility Criteria
Inclusion
- Trauma patients :
- Adult patients (age ≥ 18 years)
- Patient admitted for suspected severe trauma (1 Vittel criteria)
- Injury Severity Score ≥ 9
- Health insurance
- Written consent obtained from the patient or trusted support person / family member / close friend, or inclusion in an emergency situation and written consent obtained from the patient (trusted support person / family member / close friend if necessary) as soon as possible (article L1122-1-2 of the CSP).
- Healthy volunteers :
- Adult patients (≥ 18 years)
- Affiliated with health insurance
- Written informed consent́
- Patient respecting matching
Exclusion
- Trauma patients :
- Pregnant patient
- Minor patient
- Adult under guardianship, curatorship or safeguard of justice
- Patient under Aide Médicale d'État
- Chronic renal failure on dialysis
- Chronic respiratory disease
- Patient with chronic cardiac insufficiency
- Systemic inflammatory disease
- Healthy volunteers :
- Pregnant patient
- Minor patient
- Adult under guardianship, curatorship or safeguard of justice
- Patient under Aide Médicale d'État
- Patient with chronic renal failure on dialysis
- Chronic respiratory disease
- Patient with chronic cardiac insufficiency
- Systemic inflammatory disease
Key Trial Info
Start Date :
June 27 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 27 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06167512
Start Date
June 27 2024
End Date
October 27 2025
Last Update
July 15 2024
Active Locations (2)
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1
Bicetre hospital
Le Kremlin-Bicêtre, France, 94250
2
Bicetre hospital
Le Kremlin-Bicêtre, France, 94250