Status:
UNKNOWN
Longitudinal Neuromuscular and Metabolic Changes With Aging
Lead Sponsor:
University of Pavia
Collaborating Sponsors:
University of Padova
Politecnico di Milano
Conditions:
Aging
Muscle Physiology
Eligibility:
All Genders
55-80 years
Brief Summary
Ageing is characterized by a decline in neuromuscular control and a progressive loss of muscle mass, strength and power, leading to reduced mobility, loss of independence, higher hospitalizations rate...
Detailed Description
State of the art The life expectancy of humans has continuously increased in most countries over the last century. With extended life expectancy, quality of life of elderly is a priority. However, age...
Eligibility Criteria
Inclusion
- Community dwelling, mobility and cognitively unimpaired participants will be enrolled. Cognitive assessment: Mini Mental Status Examination (MMSE, cutoff: 24). Physical performance assessments: gait speed over 4-m (WS, \>0,8 m/s), Short Physical Performance Battery (SPPB, \>9), the Timed-Up and Go test (TUG \<20) and grip strength (GRIP, \>27 kg (M) or \>16 kg (F)).
Exclusion
- Parkinson's disease or other neurological disorder; diabetes; stroke; late-stage cancer; chronic kidney disease (IV and V stages); severe liver insufficiency; severe cardiac disorder and major recent heart surgery; severe osteoarthritis.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06168591
Start Date
May 1 2022
End Date
May 1 2025
Last Update
December 13 2023
Active Locations (1)
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1
University of Pavia
Pavia, Lombardy, Italy, 27100