Status:
COMPLETED
High-frequency tRNS for Sleep Disturbances in Neurocognitive Disorders Due to Vascular Disease
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Sleep Disorders, Circadian Rhythm
Cognitive Impairment
Eligibility:
All Genders
60-85 years
Phase:
NA
Brief Summary
The investigators aim to 1) investigate and compare the safety, efficacy and sustainability of hf-tRNS, tACS and sham transcranial current stimulation (tCS) over left inferior parietal lobe (IPL) in m...
Detailed Description
This study aims to investigate the feasibility, safety and efficacy of hf-tRNS and tACS over left IPL for sleep disturbances and cognitive dysfunction in mild NCD-vascular patients. It wills also test...
Eligibility Criteria
Inclusion
- Chinese, right-handed, aged from 60 to 80 years.
- With at least one cerebrovascular risk factor, e.g., a history of hypertension defined as systolic blood pressure (BP) 140 mm Hg or higher, diastolic BP of 90 mm Hg or higher; or receiving antihypertensive medication.
- Score of Montreal Cognitive Assessment Hong Kong version (HK MoCA) range from 22 to 26 (Lu et al., 2019).
- With preserved functional abilities reflected by a Functional Assessment Questionnaire score of 7 or lower (Hajjar et al., 2020).
- With a medial temporal lobe atrophy (MTA) score \< 2
- No interference with independence in everyday activities.
Exclusion
- Previous diagnosis of dementia or stroke;
- Past history of bipolar disorders or psychosis;
- Physically frail affecting attendance to training sessions;
- Already attending regular training, such as cognitive behavioral therapy;
- Taking a psychotropic or other medication known to affect cognition (e.g. anti-dementia medication);
- Significant communicative impairments.
Key Trial Info
Start Date :
August 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06169254
Start Date
August 1 2023
End Date
December 31 2024
Last Update
January 14 2025
Active Locations (1)
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1
The Chinese University of Hong Kong
Hong Kong, Hong Kong, 100000