Status:
RECRUITING
FDG PET/MR Imaging of Peripheral Pain Generators
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthroscopy Association of North America (AANA)
Conditions:
Pain
Nociceptive Pain
Eligibility:
All Genders
18-85 years
Brief Summary
The purpose of this research is to determine if a PET/MRI scan using FDG can accurately identify the source of chronic pain. Identifying the source of pain may help doctors treat chronic pain more eff...
Detailed Description
The investigators aim to precisely localize sites of increased inflammation and potentially pain generation and improve understanding of nociception and inflammation using a unique, hybrid PET/MRI app...
Eligibility Criteria
Inclusion
- Persistent Post-Surgical Pain Patients
- 18-85 years old
- Presents with persistent pain with pain score of ≥4 on Numerical Rating Scale \[0:10\] for at least 6 months following joint arthroplasty or arthroscopy.
- Able and willing to provide informed consent
- Willing and able to undergo PET/MRI (arthroplasty and arthroscopy participants) and PET/CT (arthroplasty participants only)
- Asymptomatic controls
- 18-85 years old
- Asymptomatic (pain score of ≤2 on the NRS) for at least 6 months following joint arthroplasty or arthroscopy.
- Able and willing to provide informed consent
- Willing and able to undergo PET/MRI
Exclusion
- Inability to understand and communicate with the investigators to complete the study-related questionnaires.
- Any co-morbidity which results in severe systemic disease limiting function as defined by the American Society of Anesthesiology (ASA) physical status classification \> 3, such as the presence of current or past (6 months) pulmonary, hepatic, renal disease, arthritis, hematopoietic, and neurological diseases not related to chronic pain.
- Pregnant or breastfeeding. (Individuals with childbearing potential will be asked to verbally confirm they are not pregnant. If they cannot confirm, they will have a urine pregnancy test either at the imaging study visit or within 7 days prior to the imaging study visit.)
- Subject with contraindication(s) to or inability to undergo PET/MRI
- Current diagnosis of malignancy of any kind. Participants in remission for at least two years and not undergoing any treatment may be considered per investigator discretion
- Current enrollment in a scientific interventional or treatment study.
- Subject unable or unwilling to provide informed consent
Key Trial Info
Start Date :
November 19 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
128 Patients enrolled
Trial Details
Trial ID
NCT06171659
Start Date
November 19 2024
End Date
June 1 2027
Last Update
September 25 2025
Active Locations (1)
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1
UW School of Medicine and Public Health
Madison, Wisconsin, United States, 53792