Status:
RECRUITING
SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
End Stage Liver Disease
Jaundice
Eligibility:
All Genders
18-80 years
Brief Summary
In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury. The pre...
Detailed Description
Portal hypertension is a major complication of cirrhosis and can lead to serious clinical manifestations such as ascites, hepatic encephalopathy, variceal bleeding, etc. Colecchia et al. proposed the ...
Eligibility Criteria
Inclusion
- Age between 18 years and 80 years
- Chronic liver diseases regardless of etiology
- Acute liver injury with total bilirubin ≥ 3 mg/dl regardless of inducement
Exclusion
- Prior surgery of liver diseases before enrollment such as liver transplantation, transjugular intrahepatic portosystemic shunt (TIPS), splenectomy and partial splenic embolization
- Severe extrahepatic diseases such as chronic obstructive pulmonary disease level IV, chronic kidney disease with end-stage renal failure, myocardial infarction within 3 months before admission
- Receiving Immunosuppressive drugs for reasons rather than chronic liver diseases
- Diagnosis of hepatocellular carcinoma or other non-liver malignancies during screening period
- Serious mental illnesses such as anxiety, depressive disorders to obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD)
- The pregnant
- Jaundice due to biliary obstruction or cholestasis
- Unsuitable to participate in this study judging by investigators
Key Trial Info
Start Date :
January 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
411 Patients enrolled
Trial Details
Trial ID
NCT06173947
Start Date
January 1 2024
End Date
December 30 2025
Last Update
May 21 2025
Active Locations (1)
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1
Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515