Status:
RECRUITING
ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Lead Sponsor:
University of Washington
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an ...
Detailed Description
Participants will be asked to enroll for 18-months. Each participant will complete 3 in-person study visits, then participate an a 6-month weight loss program delivered remotely. Some participants may...
Eligibility Criteria
Inclusion
- BMI 30.0 - 50.0 kg/m2
- Able to attend study intervention classes and study visits/assessments
- Independently living with access to food preparation facilities
Exclusion
- Current smoker or regular use of nicotine containing products and/or cannabis
- Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use
- Known cognitive impairments or h/o stroke
- Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%))
- Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate
- Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/or current breastfeeding
- Use of medications with significant effects on appetite (e.g., weight loss medications, atypical antipsychotics, stimulants) and/or chronic use of anticoagulants
- History of bariatric surgery
- History of eating disorder
- Current participation in a formal weight loss program
- Prior or current participation in a research study involving weight loss
- Weight-reduced by \>10% within past year
- Weight \> 330 pounds (MRI limit)
- Allergy or intolerance to or unwillingness to consume study foods provided at visit
- MRI contraindication (e.g., implanted metal, claustrophobia)
- Do not have a phone compatible with activity tracker or access to videoconferencing platform that will be used for the dietary intervention or other appropriate technology needed to complete study procedures
- Any condition(s) found by the study team and confirmed with the PI(s) that make it unsafe to participate
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2027
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06174389
Start Date
October 1 2023
End Date
July 31 2027
Last Update
August 29 2025
Active Locations (2)
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1
Fred Hutch Cancer Center
Seattle, Washington, United States, 98109
2
University of Washington - South Lake Union
Seattle, Washington, United States, 98109