Status:
RECRUITING
Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients
Lead Sponsor:
West China Hospital
Conditions:
Delirium
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
65-90 years
Phase:
NA
Brief Summary
Advanced age is a consistent risk factor for the incidence of postoperative cognitive decline, which is associated with longer hospital stays, decreased quality of life, and increased mortality. Anaes...
Detailed Description
With increasing life expectancy, more and more patients aged 65 or older will receive general anesthesia. Rapid recovery from anesthesia may reduce the incidence of many postoperative complications, s...
Eligibility Criteria
Inclusion
- Age ≥ 65 years and \< 90 years;
- Scheduled to undergo non-cardiac or non-neurosurgery with an expected duration of 2 hours or more, under general anesthesia;
- Agree to participate, and give signed written informed consent.
Exclusion
- Preoperative history of schizophrenia, epilepsy, parkinsonism or any diseases of central nervous system;
- Inability to communicate in the preoperative period (coma, dementia, language barrier, impaired hearing or vision);
- Severe diseases in cardiovascular, respiratory, liver, kidney, or preoperative American Society of Anesthesiologists physical status classification ≥ IV;
- Alcoholism and drug dependence;
- Other reasons that are considered unsuitable for participation by the responsible surgeons or investigators (reasons must be recorded in the case report form).
Key Trial Info
Start Date :
September 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
890 Patients enrolled
Trial Details
Trial ID
NCT06176144
Start Date
September 10 2023
End Date
September 1 2025
Last Update
June 4 2024
Active Locations (1)
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1
Department of Anesthesiology, West China Hospital
Chengdu, Sichuan, China, 610041