Status:
UNKNOWN
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
Lead Sponsor:
Xiao Chen
Conditions:
Primary Aldosteronism
Eligibility:
All Genders
18+ years
Brief Summary
This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (...
Detailed Description
1. Record the course of disease, the laboratory examination (e.g., potassium, aldosterone, aldosterone-to-renin ratio, intravenous salt-loading test or captopril test) and the results of adrenal vein ...
Eligibility Criteria
Inclusion
- Persistent hypertension with blood pressure \> 150/100 mmHg, refractory hypertension (blood pressure \>140/90 mmHg with combined use of three types of antihypertensive medications, including diuretics), or with hypokalemia of blood pressure \>140/90 mmHg;
- Refractory hypertension with an aldosterone-to-renin ratio (ARR) ≥ 2.0 (ng/dl)/(mU/L);
- Positive intravenous salt-loading test or captopril test;
- Hypertension and adrenal lesions;
- Patient ≥18 years of age at the time of consent;
- Provided written informed consent authorisation before participating in the study.
Exclusion
- Refusal by the patients to undergo CXCR4 PET imaging, adrenal vein sampling, superselective adrenal arterial embolization or adrenalectomy;
- Suspicion of familial hyperaldosteronism type 1 (FH-1) or type 3 (FH-3)；
- Suspicion of adrenocortical carcinoma；
- Severe comorbidity potentially interfering with treatment or HRQoL；
- Requirement of medication interfering with the study protocol；
- Pregnancy or lactation；
- Estimated glomerular filtration rate \<40 mL/min/1.73 m².
Key Trial Info
Start Date :
August 31 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 31 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06183554
Start Date
August 31 2023
End Date
August 31 2025
Last Update
January 3 2024
Active Locations (1)
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1
Department of Nuclear Medicine, Daping Hospital of Army Medical University
Chongqing, Chongqing Municipality, China, 400010