Status:
ACTIVE_NOT_RECRUITING
The Effect of Sedoanalgesia and General Anaesthesia on Early Neurological Recovery in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy
Lead Sponsor:
Umraniye Education and Research Hospital
Conditions:
Ischemic Stroke
Anesthesia
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The hypothesis of this study is that sedoanalgesia will provide better early neurological recovery than general anaesthesia in acute ischaemic stroke patients undergoing endovascular thrombectomy and ...
Detailed Description
Endovascular mechanical thrombectomy (EMT) is the standard emergency treatment for patients presenting with acute ischemic stroke in the anterior circulation due to urgent large vessel occlusion and s...
Eligibility Criteria
Inclusion
- Presence of cerebral ischemic embolism within the first 6 hours
- ASA 1-4
- Body mass index below 30 kg m-2
- NIHSS score ≥ 10
- Presence of isolated/combined occlusion at any level of the anterior circulation internal carotid or middle cerebral artery
Exclusion
- Chronic renal failure
- EF less than 40
- Presence of intracranial hemorrhage
- Previous known history of severe neurological disease
- Presence of bleeding diathesis
- Pre-procedure GCS ≤ 8 and intubated patients
- Failure to clearly show the site of vascular occlusion on diagnostic imaging results
- Clinical or imaging evidence of vascular occlusion that is not internal carotid artery or middle cerebral artery
- Absence of gag reflex, loss of airway protective reflex, inadequate saliva swallowing
- History of lung infection, advanced COPD or respiratory failure
- Known history of aspiration due to vomiting,
- Known history of difficult airway
- In the presence of known intolerance or allergy to certain drugs for sedation, analgesia or both
- Previously known carotid artery stenosis
- Pregnant patients
- Patients without consent
Key Trial Info
Start Date :
November 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2026
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT06183567
Start Date
November 30 2023
End Date
July 30 2026
Last Update
November 19 2025
Active Locations (1)
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1
Umraniye Education and Research Hospital
Istanbul, Umraniye, Turkey (Türkiye), 34734