Status:
RECRUITING
Multi-omics Database Construction of Healthy Korean Volunteers
Lead Sponsor:
Kyunghee University Medical Center
Collaborating Sponsors:
Hanyang University Seoul Hospital
Conditions:
Healthy
Eligibility:
All Genders
13-85 years
Brief Summary
The goal of this prospective, observational study is to collect health-related data including microbiome, blood samples, and dietary habits from the oral and gastrointestinal tracts in healthy subject...
Eligibility Criteria
Inclusion
- Subjects who are at least 13 years old and no older than 85 years old at the time of giving their informed consent.
- Subjects who have received a comprehensive explanation of this study, fully understand it, and have voluntarily agreed to participate, providing signed and dated informed consent.
- Subjects considered eligible for participation in the study by the researcher, based on screening procedures including physical examination, clinical laboratory tests, and questionnaires.
Exclusion
- Subjects with a Body Mass Index (BMI) below 17.0 or above 30.0.
- Vital signs at rest showing a systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 100 mmHg, along with symptoms related to high blood pressure such as headaches.
- History of using specified drugs within a predetermined period before microbiome collection, as detailed in the Appendix.
- Receipt of any vaccination within the last 4 weeks prior to microbiome collection.
- Use of topical antibiotics or steroids on the face, scalp, neck, arms, forearms, or hands within 24 hours before microbiome collection.
- Application of vaginal or vulvar medications, including antifungals, within 24 hours of microbiome collection.
- Presence of an acute disease at the time of enrollment. Acute disease is defined as the presence of a moderate or severe illness with or without fever. Sampling can be deferred until the subject recovers.
- History of chronic, clinically significant disorders affecting the hepatic, digestive, circulatory, renal, neurological, respiratory, endocrine, immune, or hematological systems, as well as malignant tumors, psychiatric conditions, or substance abuse.
- Substantial dietary alterations for rapid weight gain or loss within 4 weeks of the microbiome collection.
- Positive serological tests (HBs antigen, HCV antibody, and HIV antibody tests) or results above the reference range.
- History of gastrointestinal surgery, excluding simple procedures like appendectomy, cholecystectomy, or hernia repair.
- Presence of gastrointestinal conditions that may influence microbiome analysis and are not under medical control, including Inflammatory Bowel Disease (IBD) including Crohn's disease and ulcerative colitis, Irritable Bowel Syndrome (IBS) requiring medication, ulcers, acute or chronic pancreatitis, and chronic constipation requiring medication.
- Diagnosis of ankylosing spondylitis.
- Requirement for the regular use of incontinence diapers.
- Positive pregnancy test, or being pregnant or lactating.
- Any medical condition suspected at the time of microbiome collection that may affect the integrity of the sample.
Key Trial Info
Start Date :
December 29 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
3000 Patients enrolled
Trial Details
Trial ID
NCT06183697
Start Date
December 29 2023
End Date
December 31 2028
Last Update
March 28 2025
Active Locations (1)
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1
Kyung Hee University Hospital
Seoul, South Korea, 02447