Status:
RECRUITING
The Effect of Aspirin on Recurrent Acute Pancreatitis
Lead Sponsor:
Air Force Military Medical University, China
Conditions:
Recurrent Acute Pancreatitis
Prevention
Eligibility:
All Genders
14-80 years
Phase:
NA
Brief Summary
Recurrent acute pancreatitis (RAP) was defined as two or more occurrences of acute pancreatitis, which was associated with higher percentages of morbidities and mortalities, lower patients' life quali...
Eligibility Criteria
Inclusion
- Patients with with recurrent acute pancreatitis
Exclusion
- Less than 2 episodes of acute pancreatitis in the past year
- Latrogenic AP (pancreatitis due to endoscopic retrograde cholangiopancreatography, surgery, or after other invasive treatment). Iatrogenic pancreatitis will not count as an episode of recurrent pancreatitis
- Previous allergy to Non-Steroid Anti-inflammatory Drugs (NSAIDs)
- Regularly taking aspirin or other NSAIDs \>3 doses per week
- Contradictions for the medications of NSAIDs, including Active peptic ulcer disease or gastrointestinal hemorrhage within 3 months or previous peptic ulcer, history of significant hepatic or renal disease, platelet count less than 100X10\^9/L or international normalized ratio (INR) \>1.5)
- Biliary stones
- Receiving endoscopic sphincterotomy and/or pancreatic stent placement and/or cholecystectomy and/or pancreatic surgery after the latest pancreatitis or planning to undergo one of those interventions within preceding 2 years
- Patients with the level of serum triglycerides of \>5.65 mmol/L and did not receive regular lipid-lowering therapy
- Primary hyperparathyroidism has been well-treated after last episode of pancreatitis and recruitment or will be operated in \<2 years
- Patients with previously heavy alcohol consumption (50g/day for men, 40g/day for women) and have not quit drinking, or have significant withdrawal symptoms
- Pregnant or breastfeeding patients
- Inability to give informed consents
Key Trial Info
Start Date :
November 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT06185621
Start Date
November 1 2023
End Date
November 1 2026
Last Update
December 29 2023
Active Locations (1)
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1
Air Force Military Medical University, China
Xi'an, Shaanxi, China, 710032