Status:
RECRUITING
Longitudinal Multimodal Profiling of Balance and Gait In Stroke
Lead Sponsor:
Tan Tock Seng Hospital
Collaborating Sponsors:
Nanyang Technological University
Conditions:
Stroke
Eligibility:
All Genders
21-85 years
Brief Summary
Balance and gait recovery is a critical aspect of post-stroke motor rehabilitation. Researchers have effectively utilized EEG to investigate different aspects of lower limb motor control, however ther...
Detailed Description
Brain Computer Interface represent a groundbreaking field at the crossroads of neuroscience and engineering, serving as a direct communication link between the human brain and computer system. Despit...
Eligibility Criteria
Inclusion
- First-ever clinical stroke (ischaemic or haemorrhagic) confirmed by admitting doctors brain imaging
- Age 21 to 85 years
- At least ≥ 30 days post-stroke
- Gait impairments related to stroke
- Functional ambulation category -6 levels (Mehrholz et al, 2007): FAC ≥ 4, i.e. able to ambulate independently on level surface but requires supervision to negotiate (e.g. stairs, inclines, non-level surfaces).
- Montreal Cognitive Assessment (MoCA) score \> 21 (Nasreddine et al., 2005)
- Able to understand study instructions and requirements
Exclusion
- Non-stroke related causes of gait impairment
- Medical conditions incompatible with research participation: uncontrolled medical illnesses (hypertension or diabetes, ischaemic heart disease, congestive heart failure, bronchial asthma, severe /untreated depression, agitation, end stage renal/liver/heart/lung failure, dialysis, unresolved cancers e.g.,), active seizures within 3 months
- Anticipated life expectancy of \< 6 months
- On subcutaneous or oral anti-coagulation
- Local factors potentially worsened by gait training: joint and muscle pains
- Lower limb pain VAS \>4/10, active lower limb fractures or arthritis, fixed leg contractures, severe peripheral vascular disease, organomegaly or aortic aneurysms
- Active unhealed skin wounds or inflammatory skin conditions over trunk and lower limbs,
- Severe visual impairment or visual neglect affecting navigation
- Known allergy to EEG gel (Recoverix)
- Presence of craniectomy skull defect
- Resident of nursing home or overseas country which may compromise attendance at research site
- Pregnant or lactating females
Key Trial Info
Start Date :
July 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06187467
Start Date
July 1 2024
End Date
October 1 2025
Last Update
April 11 2025
Active Locations (1)
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1
Tan Tock Seng Hospital
Singapore, Singapore, Singapore