Status:
RECRUITING
Eosinopenia in Severe COPD Exacerbation
Lead Sponsor:
Northumbria Healthcare NHS Foundation Trust
Collaborating Sponsors:
Newcastle University
Chiesi UK
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
35+ years
Brief Summary
The goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD)...
Detailed Description
Blood eosinophils are a type of white blood cell that play a role in the immune system including fighting infection. They have numerous roles but are primarily involved in inflammation. They are recru...
Eligibility Criteria
Inclusion
- Admitted to hospital with primary clinical diagnosis of exacerbation of COPD\*
- Smoking history of at least 10 pack years
- Airflow obstruction: FEV1/FVC ratio \< 0.7 confirmed on historic or inpatient spirometry
- Capacity to give informed consent to participate
Exclusion
- Parasitic infection, systemic fungal infection (excluding infection limited to nails or skin), eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome or other conditions associated with a high eosinophil count#
- Active malignancy
- Maintenance oral prednisolone or other systemic steroids, anti-interleukin 5 therapy or other medication known to influence eosinophils
- Patients with poor venous access
- Investigator confirmed history of asthma
- Non-COPD related health problems which in the view of the primary investigator may compromise the conduct and completion of the study
- ADDITIONAL CRITERIA FOR THE TIME TO RECOVERY FROM EOSINOPENIA ANALYSIS ONLY
- Inclusion criteria:
- Eosinopenia on admission
- Uneventful recovery\*
- Eosinopenia on admission who do not receive a further course of systemic corticosteroids or require emergency hospital admission for an acute illness in the six weeks following admission to hospital with a severe exacerbation of COPD.
Key Trial Info
Start Date :
January 22 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06188065
Start Date
January 22 2024
End Date
July 1 2026
Last Update
March 28 2025
Active Locations (1)
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1
Northumbria Healthcare NHS Foundation Trust
North Shields, United Kingdom