Status:
RECRUITING
Fatty Acid Modulation of Brain Function in Older Adults
Lead Sponsor:
University of Vermont
Conditions:
Aging
Eligibility:
All Genders
65-75 years
Phase:
NA
Brief Summary
In this crossover study, the investigtors will administer two experimental diets in a random order for one week, and each experimental diet will be preceded by a one-week, low fat control diet for a t...
Detailed Description
This study will examine how manipulating dietary fatty acids affects brain functioning in older adults. Prior studies have shown that there are behavioral changes that can be made to improve cognition...
Eligibility Criteria
Inclusion
- Men and women age range 65-75 years
- Normal cognition (see Research Strategy for details on cognitive assessments)
- "Healthy" (body mass index (BMI) of 20-40 kg/m2)
Exclusion
- Significant cognitive or behavioral impairment (see Research Strategy for testing and exclusions) or pharmacological treatment for this (e.g. antipsychotics, anxiolytics, and sedative medications).
- Hormone replacement therapy, past 3 months.
- Hyper-androgenic condition.
- HbA1C≥7.5% and or Fasting plasma glucose concentration ≥130 mg/dL.
- Type 2 Diabetes if receiving any other therapy than metformin.
- Use of nicotine or ingestion of caffeine or alcohol during the study.
- Habitual fat intake \< 25% of kcal or strict vegetarian diet.
- Sleep apnea requiring continuous positive airway pressure at night.
- Lung, cardiac (heart failure or its treatment), liver disease, renal disease, cancer, and any other medical disorder known or thought to cause inflammation or abnormalities of cognition
- Actively training for an athletic event or participating in competitive sports (such as league play or tournaments)
- Intolerance or allergy to any of the food provided in the study.
Key Trial Info
Start Date :
April 15 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2028
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06192407
Start Date
April 15 2024
End Date
October 31 2028
Last Update
September 17 2025
Active Locations (1)
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1
University of Vermont
Burlington, Vermont, United States, 05401