Status:
RECRUITING
A Study on the Effect of High-concentrated Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base.
Lead Sponsor:
Karolinska Institutet
Conditions:
Osteoarthritis Thumb
Eligibility:
All Genders
Phase:
NA
Brief Summary
This is a randomized double-blinded randomized comparison between injection of platelet rich plasma (PRP) and placebo for thumb basale osteoarthritis.
Detailed Description
The aim of this study is to evaluate if high-concentration PRP injection decreases pain and disability in patients with thumb base osteoarthritis in the short-term and compare the effect to placebo.90...
Eligibility Criteria
Inclusion
- Osteoarthritis in the thumb base
- Radiological Eaton Littler class 1-3.
- Clinical signs of thumb base osteoarthritis )pain at palpation of the CMC-1 joint and pain during provocation/grinding test).
Exclusion
- Rheumatoid arthritis
- Ongoing infection in the hand or wrist
- History of gout or pseudogout in the hand
- Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction).
- Chronic pain syndrome / centralized pain.
- Intra-articular injection in the affected joint within 6 months.
- Eaton Littler class 4 (symptomatic STT joint osteoarthritis).
Key Trial Info
Start Date :
January 17 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06193499
Start Date
January 17 2024
End Date
June 30 2027
Last Update
June 3 2025
Active Locations (1)
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1
Department of Hand Surgery Södersjukhuset
Stockholm, Sweden, S-11883