Status:
RECRUITING
ICU Combined Assessment of Cardio-Respiratory Exercise
Lead Sponsor:
University of Manitoba
Conditions:
ICU Acquired Weakness
Sepsis
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle we...
Detailed Description
This longitudinal study will assess cardiovascular fitness and microvascular function through two (2) follow-ups after ICU discharge: at (i) 6 months, and (ii) 12 months. The goal is to understand how...
Eligibility Criteria
Inclusion
- Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.
Exclusion
- Unable to provide consent
- Trajectory of health expected to be significantly limited in the upcoming 12 months
- those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity
- have significant orthopedic or musculoskeletal impairment affecting mobility
- have a medical history of neuromuscular disease
- ongoing respiratory limitations (i.e., supplemental oxygen)
- significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)
- a body mass index (BMI) of ≥ 40 kg/m2 (impacting NIRS signal due to adipose tissue thickness)
- if participant's primary residence is a significant distance from Winnipeg
Key Trial Info
Start Date :
December 15 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06193980
Start Date
December 15 2023
End Date
July 1 2028
Last Update
November 28 2025
Active Locations (1)
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1
Health Sciences Centre Winnipeg
Winnipeg, Manitoba, Canada, R3A 1R9