Status:
RECRUITING
Genetic Association With Various Severities, Phenotypes and Endotypes of Asthma.
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Asthma
Eligibility:
All Genders
18-100 years
Brief Summary
There is limited information on genetics associated with asthma in Chinese. An earlier meta-analysis found that ADAM33, FcεRIb, RANTES, TNF-a, ACE, b2-AR, IL-4R and IL-13 genes could be proposed as as...
Detailed Description
Currently, many studies on asthma genetics are limited by the dominance of populations of European descent. In addition, there are few genetic studies that focus on moderate-to-severe asthma. There i...
Eligibility Criteria
Inclusion
- • All patients with confirmed diagnosis of asthma (defined as those with a consistent history and prior documented evidence of variable airflow obstruction, with evidence of an increase in FEV1 greater than 12% or 400 mL following bronchodilator or bronchial hyperresponsiveness on bronchial provocation testing, when stable) 12
- Able to sign written informed consent form to participate in the study.
Exclusion
- • Patients currently with acute exacerbation of asthma by GINA guideline. (For subjects with asthma exacerbation, they can join the study after 6 weeks post recovery from the exacerbation.)
- Patients with respiratory diseases that can show similar symptoms to chronic airway diseases such as bronchiectasis, tuberculosis(TB)-destroyed lung parenchyma, endobronchial TB, and lung cancer, or those who have history of these diseases based on physician's judgment.
- Patients currently diagnosed with pneumonia and acute bronchitis.
- For control subject: the inclusion will be having no clinical diagnosis of asthma.
Key Trial Info
Start Date :
March 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 4 2029
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT06196034
Start Date
March 1 2024
End Date
January 4 2029
Last Update
August 21 2024
Active Locations (2)
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1
The Chinese University of Hong Kong
Hong Kong, New Territories, Hong Kong
2
The Chinese University of Hong Kong
Hong Kong, Hong Kong