Status:
RECRUITING
A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Parkinson Disease
Eligibility:
All Genders
20+ years
Phase:
NA
Brief Summary
The concept of "Microbiota-gut-brain axis" has long been elucidated. However, only few microbiota-related radionuclide imaging studies have been published. The etiology of physiologic bowel FDG uptake...
Detailed Description
The key role of gut microbiota in keeping local and systemic homeostasis is termed the "Microbiota-gut-brain axis", which is a complex bidirectional communication system between the gastrointestinal t...
Eligibility Criteria
Inclusion
- 80 Parkinson's disease patients over 20 years old (the Unified Parkinson's Disease Rating Scale and Hoehn-Yahr Grading Scale are required to provide clinical staging).
- 20 non-Parkinson's disease patients over 20 years old (control group).
- Those who are not currently using Metformin, can tolerate fasting for 8 hours, have not used antibiotics within 3 months, and have no obvious intestinal diseases.
- Subjects and their families agree to join the trial and agree to undergo fluorine-18 deoxyglucose positron imaging (100 subjects will be paid for by research funds) and phosphonium-99m dopamine transporter scan (20 non-Parkinson's patients will be paid for by research funds) syndrome patients) examination.
Exclusion
- Unable to accept positron or single photon angiography such as checking for panic disorder and hemodynamic instability.
- The possible cancer risk caused by the radiation dose obtained from the experiment cannot be accepted.
- Pregnant women or women currently breastfeeding.
- There is a lack of recent unified Parkinson's disease rating scale and Hoehn-Yahr grading scale, making it impossible to know the clinical stage.
- Those who are currently using Metformin, cannot tolerate fasting for 8 hours, have used antibiotics within 3 months, and have obvious intestinal diseases.
- The subjects and their families do not agree to join the trial.
Key Trial Info
Start Date :
January 3 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06197698
Start Date
January 3 2023
End Date
February 28 2025
Last Update
October 21 2024
Active Locations (1)
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1
National Taiwan University Hospital Yunlin branch
Douliu, Taiwan