Status:
COMPLETED
Personalized Noninvasive Support in Acute Hypoxemic Respiratory Failure
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Acute Hypoxic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The optimal noninvasive respiratory support for acute hypoxemic respiratory failure is debated. Recent preliminary data indicate that both pressure-support noninvasive ventilation (NIV) and continuous...
Detailed Description
Patients with acute hypoxemic respiratory failure will undergo a decremental pressure-support trial during helmet noninvasive support. The following pressure-support settings will be applied sequentia...
Eligibility Criteria
Inclusion
- Acute hypoxemic respiratory failure and PaO2/FiO2\<200 mmHg
- PaCO2\<45 mmHg
- Respiratory failure not caused by exacerbation of chronic pulmonary disease, cardiac failure or fluid overload
Exclusion
- Pregnancy
- Contraindication to helmet support
- Contraindication to esophageal manometry
- Contraindication to electrical-impedance tomography monitoring
- Recent surgery involving the abdomen or the thorax
- Pneumothorax or documented barotrauma
Key Trial Info
Start Date :
January 12 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 15 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06202144
Start Date
January 12 2024
End Date
June 15 2025
Last Update
September 30 2025
Active Locations (1)
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1
Fondazione Policlinico Universitaro A. Gemelli IRCCS
Rome, Italy