Status:
COMPLETED
Prehabilitative Exercise Prior to Immobilization
Lead Sponsor:
Bispebjerg Hospital
Conditions:
Sarcopenia
Skeletal Muscle Atrophy
Eligibility:
All Genders
20-85 years
Phase:
NA
Brief Summary
This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 ...
Eligibility Criteria
Inclusion
- Age: Between 20-35 years old or between 65-85 years old.
- BMI: Between 18.5 and 35 kg/m2.
- Healthy and well, with normal dietary habits (not vegan).
Exclusion
- More than one muscle biopsy previously taken from both vastus lateralis muscles.
- Smoking.
- Pregnancy.
- Past or present substance or alcohol abuse.
- Medical/surgical conditions that are assessed to affect protein synthesis or the participant's involvement in the trial.
- Knee pain that could affect the completion of the training intervention.
- High intake of supplements that increase the risk of bleeding during muscle biopsy (such as fish oil and ginger).
- Participation in regular strength training within the past year.
- Regular participation in structured sports.
- Current use of blood-thinning medication.
- Previous participation in trials involving oral intake of heavy water.
- Metal in the body preventing MRI scanning.
- For the older group, not having gone through menopause, and for the younger group, not having a regular menstrual cycle.
Key Trial Info
Start Date :
January 6 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2025
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06205784
Start Date
January 6 2024
End Date
June 1 2025
Last Update
September 19 2025
Active Locations (1)
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1
Institute of Sports Medicine Copenhagen
Copenhagen, Capital Region, Denmark, 2400