Status:
RECRUITING
The Anesthesia Effects of Dexmedetomidine Combined With Desflurane or Propofol in Lobectomy
Lead Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Conditions:
Anesthesia Recovery Period
Postoperative Complications
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In one-lung ventilation surgery, compared with dexmedetomidine combined with propofol, dexmedetomidine combined with desflurane may be beneficial to accelerate patients' recovery and reduce postoperat...
Detailed Description
With the increase in the prevalence of lung cancer in recent years, the number of patients undergoing lobectomy has also increased. When performing lobectomy, inserting a double-lumen endotracheal tub...
Eligibility Criteria
Inclusion
- Patients undergoing elective thoracoscopic unilateral lobectomy.
- General anesthesia is required and the expected duration of one-lung ventilation is ≥ 1h.
- American Association of Anesthesiologists (ASA) physical condition classification I-III.
- Patients over 18 years old.
- Voluntary participation and ability to understand and sign the informed consent.
Exclusion
- Obese patients (BMI\>28 kg/m2).
- patients with grade 3 hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg).
- Acute coronary syndrome, sinus bradycardia (heart rate \< 45 beats/min), II or III degree atrioventricular block, NYHA heart function classification III or IV.
- Patients with severe history of chronic obstructive pulmonary disease (GOLD grade III or IV of pulmonary function of chronic obstructive pulmonary disease), severe or uncontrolled bronchial asthma, pulmonary infection, bronchiectasis and thoracic deformity.
- Pulmonary artery pressure ≥60 mmHg.
- Patients with Child grade B or C of liver function.
- Patients with chronic kidney disease in stage 4 or 5.
- Patients with hyperthyroidism and pheochromocytoma.
- Patients who are expected to need mechanical ventilation after operation.
- People with hearing, intelligence, communication and cognitive impairment.
- For any reason, it is impossible to cooperate with the study or the researcher thinks that it is not suitable to be included in this experiment.
- patients who are expected to be transferred to ICU after operation.
Key Trial Info
Start Date :
October 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06207344
Start Date
October 21 2023
End Date
June 30 2025
Last Update
March 13 2024
Active Locations (2)
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1
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400000
2
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400000