Status:
RECRUITING
Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis
Lead Sponsor:
Assiut University
Conditions:
Bronchiectasis With Acute Exacerbation
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-c...
Detailed Description
Bronchiectasis is a chronic suppurative and inflammatory lung disease of diverse etiology characterized by pathological and irreversible dilatation of the bronchial tree. The impairment of the mucocil...
Eligibility Criteria
Inclusion
- patients with bronchiectasis confirmed by high-resolution CT chest(HRCT)
- patients with acute exacerbation of bronchiectasis who need antibiotic treatment at the hospital due to exacerbation
- mechanically ventilated patients in the respiratory ICU
- Age more than or equal to 18 years
Exclusion
- patients with active pulmonary tuberculosis
- patients with allergic bronchopulmonary aspergillosis
- patients who underwent interventional bronchoscopy for hemoptysis
- age less than 18 years
Key Trial Info
Start Date :
October 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
315 Patients enrolled
Trial Details
Trial ID
NCT06209047
Start Date
October 15 2023
End Date
February 1 2027
Last Update
July 17 2025
Active Locations (1)
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1
Assiut university hospitals
Asyut, Egypt, 71515